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Factors associated with a conduit leak includedinvolvement of R2 surgical margins (43%) the magnitude of the exenteration and acurrent cardiovascular medical history (27%). Therefore the vast majority of published studies are based on homog-enized bone samples, and the total drug concentrations in bone homogenate are reported.For the interpretation of bone penetration results, it is important to note that only freedrug is microbiologically active

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So, in the finalhazard assessment for a chemical, a toxicologist would liketo review as much human data as are available. This results in thephosphorylation of STAT5 and Shc, which leads to continual FOXP3 expression

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